Familiarity-based stimulus generalization of conditioned suppression in rats is dependent on the perirhinal cortex.

Robinson, Jasper, Whitt, Emma J, Horsley, Rachel R and JONES, Peter M (2010) Familiarity-based stimulus generalization of conditioned suppression in rats is dependent on the perirhinal cortex. Behavioral Neuroscience, 124 (5). pp. 587-99. ISSN 1939-0084

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Abstract or description

We report that bilateral, excitoxic lesions of the perirhinal cortex attenuate rats' familiarity-based stimulus generalization. After surgery, rats were preexposed either to 2 auditory stimuli (A and B) or to only 1 auditory stimulus (B). Following preexposure, all rats received pairings of A and a footshock before assessment of generalized responding (conditioned suppression) to B. Sham rats' generalization was greater when preexposure was to both A and B than when preexposure was to B only. That pattern was abolished in lesioned rats, though no general deficiency was found in other measures of auditory processing. Our findings suggest that the perirhinal cortex is required for rats to encode familiarity as part of stimulus representations.

Item Type:	Article
Faculty:	Previous Faculty of Health Sciences > Psychology, Sport and Exercise
Depositing User:	Peter JONES
Date Deposited:	05 Feb 2013 19:18
Last Modified:	24 Feb 2023 13:36
URI:	https://eprints.staffs.ac.uk/id/eprint/348

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