Staffordshire University logo
STORE - Staffordshire Online Repository

Association between depot medroxyprogesterone acetate (DMPA), physical activity and bone health

BABATUNDE, Opeyemi and FORSYTH, Jacky (2013) Association between depot medroxyprogesterone acetate (DMPA), physical activity and bone health. Journal of Bone and Mineral Metabolism, n/a (n/a). p. 1. ISSN 0914-8779

Full text not available from this repository.

Abstract or description

Physical activity has been advocated for women in the hope of offsetting progestin-only contraceptive-related loss in bone mineral density. There is limited evidence for the beneficial effect of physical activity on bone health of hypo-oestrogenic premenopausal women. The aim of this cross-sectional study was to examine the relationship between physical activity and bone health [as measured by quantitative ultrasound (QUS)] of depot-medroxyprogesterone acetate (DMPA) users, and to investigate whether QUS measurements of DMPA users and non-users differed according to physical activity. Bone health of 48 DMPA users and 48 age-matched controls (22.83 ± 3.2 years) was assessed using calcaneal broadband ultrasound attenuation (BUA). Participants were categorised into low and high levels of physical activity based on their exposure to bone-loading exercise. Analysis of covariance was conducted to determine if QUS measurements of DMPA users and non-DMPA users differed within levels of bone-loading physical activity after controlling for body mass index. The duration of DMPA use ranged from 6 to 132 months. Participants’ reference bone-loading exposure time averaged 3.3 ± 1.8 years. Data analysis revealed that DMPA users had significantly lower BUA by 6.54 dB/MHz (t (95) = −2.411, p = 0.018) compared to non-users of DMPA. Concurrently high levels of physical activity and DMPA use led to 1.996 dB/MHz decreases in BUA. A cycle of prolonged DMPA use and concurrent engagement in high levels of physical activity appears detrimental to bone health. It is suggested that the lack of oestrogen may counteract the effects of physical activity by inhibiting bone formation in response to mechanical bone-loading.

Item Type: Article
Subjects: B100 Anatomy, Physiology and Pathology
C600 Sports Science
Faculty: Previous Faculty of Health Sciences > Psychology, Sport and Exercise
Depositing User: Jacky FORSYTH
Date Deposited: 20 Sep 2013 09:32
Last Modified: 19 Apr 2017 11:19
URI: http://eprints.staffs.ac.uk/id/eprint/1580

Actions (login required)

View Item View Item

DisabledGo Staffordshire University is a recognised   Investor in People. Sustain Staffs
Legal | Freedom of Information | Site Map | Job Vacancies
Staffordshire University, College Road, Stoke-on-Trent, Staffordshire ST4 2DE t: +44 (0)1782 294000