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Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study

Tsitsilonis, Serafim and Panayiotis, Chatzistergos E. and Athanasios, Mitousoudis S. and Stavros, Kourkoulis K. and Ioannis, Vlachos S. and George, Agrogiannis and Konstantinos, Fasseas and Despina, Perrea N. and Aristides, Zoubos B. (2014) Anabolic androgenic steroids reverse the beneficial effect of exercise on tendon biomechanics: An experimental study. Foot and Ankle Surgery, 20 (2). pp. 94-99. ISSN 1268-7731

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Abstract or description

Background
The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons.
Methods
Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons’ biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed.
Results
In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise.
Conclusions
These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values.

Item Type: Article
Faculty: Faculty of Health Sciences > Psychology, Sport and Exercise
Depositing User: Panagiotis CHATZISTERGOS
Date Deposited: 09 Nov 2016 12:01
Last Modified: 14 Dec 2016 10:18
URI: http://eprints.staffs.ac.uk/id/eprint/2897

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