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Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics

Doulamis, Ilias and CHATZISTERGOS, Panagiotis and Mitousoudis, Athanasios and Kourkoulis, Stavros and Perrea, Despina (2017) Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics. Frattura ed Integrità Strutturale. ISSN 1971-8993

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Abstract or description

The aim of this study is to investigate whether exercise can
reverse some of the adverse effects of high-fat-diet-induced obesity on lipid
metabolism and bone biomechanical properties. A total of 26 adult male
C57bl/6J mice were randomly assigned into three groups: (A) Control group
(n=6), (B) High-fat diet group (n=10), (C) High-fat diet and exercise group
(n=10). Body mass and relevant biochemical parameters were measured for
the duration of the experimental protocol (37 weeks). Mechanical strength of
both femurs of each animal was assessed in-vitro based on three point bending
tests. It was revealed that exposure to high-fat diet led to significant increase
of body mass and cholesterol levels and also to substantial changes in bone
morphology and strength. Ultimate stress for the animals exposed to high-fat
diet and those exposed to high-fat-diet and exercise was 25% and 24% lower
compared to control, respectively. Exercise increased bone thickness by 15%
compared to animals that were not exposed to exercise. It was concluded that
high-fat-diet appears to have a detrimental effect on bone biomechanics and
strength. Exercise reversed the reduction in bone thickness that appears to be
induced by high-fat diet. However no statistically significant increase in bone
strength was observed.

Item Type: Article
Faculty: Previous Faculty of Health Sciences > Psychology, Sport and Exercise
Depositing User: Panagiotis CHATZISTERGOS
Date Deposited: 11 May 2017 09:06
Last Modified: 11 May 2017 14:42
URI: http://eprints.staffs.ac.uk/id/eprint/3067

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