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Novel Ferrocenyl Chalcone Compounds as Possible Antimicrobial Agents

HENRY, Elecia and Smith, Robert and Collins, Michael and BIRD, Susan and GOWLAND, Pauline and CASSELLA, John (2017) Novel Ferrocenyl Chalcone Compounds as Possible Antimicrobial Agents. In: “Antimicrobial Research: Novel bioknowledge and educational programs. Microbiology Book Series, 40 (6). Formatex Research Center, Badajoz, Spain, pp. 140-148. ISBN 978-84-947512-0-2

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Abstract or description

The increased presence of drug-resistant bacteria has quickly become a worldwide concern as infections spread from healthcare settings to the wider community. The swift spread of infections caused by bacteria such as methicillin-resistant
Staphylococcus aureus (MRSA) is influenced by factors such as misuse and abuse of traditional antimicrobial treatments and inferior drugs. Ferrocenyl chalcones, which are derivatives of plant-based flavonoids, have gained further attention
from researchers because of their antimicrobial activity. Using 2-fold broth microdilution, results demonstrated that 5 of the 10 newly developed ferrocenyl chalcones, which contain increasing alkyl chains from 5-10 carbons on ring B,
possessed greater antimicrobial activity against Gram-positive organisms than Gram-negative organisms. These novel compounds were active against 3 types of drug-resistant S. aureus, including a MRSA, and other non-resistant Grampositive
bacteria. The same compounds inhibited growth by potentially obstructing cellular respiration in Gram-positive bacteria. Images obtained through scanning electron microscopy revealed bacterial cells with severe external damage once
exposed to a selected compound that showed activity. Findings indicate that these newly developed compounds could be important antimicrobial agents in the treatment of infections from clinically resistant bacteria.

Item Type: Book Chapter, Section or Conference Proceeding
Faculty: School of Law, Policing and Forensics > Criminal Justice and Forensic Science
Depositing User: John CASSELLA
Date Deposited: 07 Jul 2017 09:09
Last Modified: 11 Sep 2017 14:03
URI: http://eprints.staffs.ac.uk/id/eprint/3662

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