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Characteristics of patients with future diabetic foot ulceration. Can those be used to predict the ulceration incident?

NAEMI, Roozbeh, Balasubramanian, Gayathri, Darvel, Tracey and CHOCKALINGAM, Nachiappan (2021) Characteristics of patients with future diabetic foot ulceration. Can those be used to predict the ulceration incident? In: unspecified Wiley.

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Abstract or description

Aims: The aim of this study was to investigate if clinical assessment during foot check-up can be used to predict the diabetic foot ulceration in people with diabetes.

Methods: Following ethical approval, data from 203 (M/F: 99/104) patients with diabetes who visited the foot clinic from January 2017 to December 2018 were collected. A set of demographic and generic clinical as well as the foot specific parameters were collected from participants. The foot-specific parameters included: muscle wasting, dry skin, Tinea pedis, Onychomycosis, foot deformity, Callus, nail deformity and neuropathy measures. Ankle Brachial Pressure Index (ABPI) was measured to assess vascular sufficiency. During a 2-year follow-up 24 (M/F: 17/7) participants ulcerated.

Results: Mann-Whitney U test indicated that participants who ulcerated had significantly (p < 0.05) higher: weight (r = 0.32), HbA1C (r = 0.20), and creatinine (r = 0.19), while they were more likely to be male (χ(1)=5.30), and have history of ulceration (χ(1) = 5.30) or amputation (χ(1) = 8.79). Logistic regression analysis indicated that the prediction accuracy of the model was 92% (sensitivity: 65% and specificity: 96%). The presence of nail deformity and ulceration history, absence of sensation to monofilament, and presence of numbness in the foot were the only parameters that were statistically significant in the model.

Conclusions: People with diabetes who are more vulnerable to future diabetic foot ulceration have few distinct characteristics which can be used to distinguish them from those who don’t ulcerate. Previous ulcer, and presence of neuropathy and nail deformity can be used to predict ulceration incident in 2 out of 3 cases.

Item Type: Book Chapter, Section or Conference Proceeding
Additional Information: "The following article is published in : Special Issue: Abstracts of the Diabetes UK Professional Conference 2021, 19 to 30 April 2021, Online, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."
Uncontrolled Keywords: Diabetic foot, Ulcers, prognosis, prediction, plantar soft tissue,
Faculty: School of Life Sciences and Education > Sport and Exercise
Depositing User: Roozbeh NAEMI
Date Deposited: 03 Sep 2021 15:03
Last Modified: 26 Apr 2024 11:52

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