Connected to Death: The (Unexpurgated) Mitochondrial Pathway of Apoptosis

Spierings, D., MCSTAY, Gavin, Saleh, M., Bender, C., Chipuk, J., Maurer, U. and Green, DR. (2005) Connected to Death: The (Unexpurgated) Mitochondrial Pathway of Apoptosis. Science, 310 (5745). pp. 66-67. ISSN 0036-8075

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Abstract or description

The mitochondrial pathway of apoptosis in vertebrates is dependent on the process of mitochondrial outer membrane permeabilization (MOMP), which leads to the release of proteins from the mitochondrial intermembrane space into the cytosol. "Upstairs" of this event are the Bcl-2 family proteins that regulate and mediate MOMP; "downstairs" is the activation of caspases that orchestrate the dismantling of the cell. In the Connections Map database at Science's Signal Transduction Knowledge Environment (STKE), the pathways that define the mitochondrial pathway of apotosis are illustrated, with the bulk of control occurring "upstairs" of MOMP.

Item Type:	Article
Faculty:	School of Life Sciences and Education > Biological Sciences
Depositing User:	Gavin MCSTAY
Date Deposited:	20 Mar 2019 10:23
Last Modified:	24 Feb 2023 13:55
URI:	https://eprints.staffs.ac.uk/id/eprint/5465

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