Effects of Obesity on Medial Tibiofemoral Cartilage Mechanics in Females—An Exploration Using Musculoskeletal Simulation and Probabilistic Cartilage Failure Modelling
Lists
Lists
SINCLAIR, Jonathan, Lynch, Holly, CHOCKALINGAM, Nachiappan and Taylor, Paul John (2023) Effects of Obesity on Medial Tibiofemoral Cartilage Mechanics in Females—An Exploration Using Musculoskeletal Simulation and Probabilistic Cartilage Failure Modelling. Life, 13 (2). p. 270. ISSN 2075-1729
|
Text
life-13-00270.pdf - Publisher's typeset copy Available under License Creative Commons Attribution 4.0 International (CC BY 4.0) . Download (1MB) | Preview |
Abstract or description
This study examined the effects of obesity on cartilage mechanics and longitudinal failure probability at the medial tibiofemoral compartment, using combined musculoskeletal simulation and probabilistic failure modelling approaches. The current investigation examined twenty obese females (BMI > 30.0 kg/m2) and 20 healthy weight (BMI < 25.0 kg/m2) females. Walking kinematics were obtained via an 8-camera optoelectric system, and a force plate was used to collect ground reaction forces. Musculoskeletal simulation and probabilistic failure modelling were utilized to explore medial tibiofemoral forces and cartilage probability. Comparisons between groups were undertaken using linear mixed-effects models. Net peak cartilage forces, stress and strain were significantly larger in the obese group (force = 2013.92 N, stress = 3.03 MPa & strain = 0.25), compared to health weight (force = 1493.21 N, stress 2.26 MPa & strain = 0.19). In addition, medial tibiofemoral cartilage failure probability was also significantly larger in the obese group (42.98%) compared to healthy weight (11.63%). The findings from the current investigation show that obesity has a profoundly negative influence on longitudinal medial knee cartilage health and strongly advocates for the implementation of effective weight management programs into long-term musculoskeletal management strategies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | biomechanics; obesity; osteoarthritis; cartilage; musculoskeletal simulation; probabilistic modelling |
| Faculty: | School of Life Sciences and Education > Sport and Exercise |
| Depositing User: | Nachiappan CHOCKALINGAM |
| Date Deposited: | 14 Feb 2023 10:03 |
| Last Modified: | 24 Feb 2023 14:05 |
| URI: | https://eprints.staffs.ac.uk/id/eprint/7639 |
Actions (login required)
 |
View Item |
