Staffordshire University logo
STORE - Staffordshire Online Repository

Symptoms of depression in late pregnancy are associated with increased salivary alpha-amylase levels

BRAITHWAITE, Elizabeth, Ramchandani, P, Lane, Tracy and Murphy, Susannah (2015) Symptoms of depression in late pregnancy are associated with increased salivary alpha-amylase levels. Psychoneuroendocrinology, 60. pp. 163-172. ISSN 0306-4530

[img] Text
Braithwaite et al PNEC 2015 ACCEPTED.docx - AUTHOR'S ACCEPTED Version (default)
Available under License Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0).

Download (148kB)

Abstract or description

Prenatal depression increases risk for a number of adverse offspring outcomes, however the biological mechanisms underlying this association remain unclear. It has been suggested that maternal glucocorticoids may mediate this link, though supporting evidence has been mixed. An alternative mechanism of effect may be via depression-induced changes in maternal sympathetic nervous system (SNS) function. We examined this hypothesis by determining the relationship between symptoms of maternal prenatal depression and diurnal salivary alpha-amylase (sAA) levels.
76 pregnant women were recruited during either the second or third trimester of pregnancy. Participants self-reported depressive symptoms using the Edinburgh Postnatal Depression Scale. Saliva samples, to be assayed for alpha-amylase activity, were collected at home over two working days.
Participants with depressive symptoms in later pregnancy, had elevated awakening sAA levels compared with non-depressed controls (t(73)=-2.737, p=0.008), and continued to have raised sAA throughout the day (F(1)=10.924, p=0.002).
Our findings highlight that symptoms of depression during late pregnancy are associated with increased maternal SNS activity. Thus, changes in maternal SNS function, which may include increased vasoconstriction and reduced fetal blood flow, could, in part, mediate associations between prenatal depression and adverse offspring outcomes.

Item Type: Article
Faculty: School of Life Sciences and Education > Biological Sciences
Depositing User: Andrew LITTLE
Date Deposited: 14 Nov 2017 13:01
Last Modified: 24 Feb 2023 13:49

Actions (login required)

View Item View Item

DisabledGo Staffordshire University is a recognised   Investor in People. Sustain Staffs
Legal | Freedom of Information | Site Map | Job Vacancies
Staffordshire University, College Road, Stoke-on-Trent, Staffordshire ST4 2DE t: +44 (0)1782 294000